Singh Lab
Aberrant protein synthesis is frequently observed in cancer however a transcriptome-wide translation landscape in cancer is largely unknown. RNA binding proteins in conjunctions with regulatory RNA controls translation program in a cell type and state-specific manner. We are interested in characterizing the translational landscape in cancer and microenvironment using the advanced single-cell methodology and sequencing tools that enable us to precisely measure translation efficiency and map translation start sites. Our studies will define the “molecular basis of translation reprogramming in MYC and KRAS driven cancer and microenvironment”.Long-term goal of our research team is to study the cell type and state-specific translation programs in cancer and identify new actionable and druggable therapeutic targets based on inhibiting cancer-specific translation programs.
The Team
We are looking for postdoctoral fellows and students to join our team.
Please email at kamini.singh@einsteinmed.edu
Kamini Singh, PhD
Lab Director
"I am a Cancer Biologist by training. Some of my favorite genes are KRAS, MYC, and TP53. I am fascinated by molecular machines particularly ribosomes. In our lab, we try to understand the basic mechanism of protein synthesis and RNA regulation in cancer to identify the druggable mechanisms.
Other than my love for Ribosomes, I like science fiction, electric cars, spaceships, and everything about the mission to Mars".
​
![Headshot_Trang Uyen Nguyen[1].jpg](https://static.wixstatic.com/media/dd933b_24939fa67dc24c959746db21e4567c69~mv2.jpg/v1/fill/w_184,h_265,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/Headshot_Trang%20Uyen%20Nguyen%5B1%5D.jpg)
Trang Uyen Nguyen
Research Technician
"I’m a recent college graduate with a background in Neuroscience and Computer Science, and I absolutely love working with rodent models of human disease. I'm excited about our lab’s research on translation programs in cancer, and looking forward to picking up new skills along the way. In my free time I like reading speculative fiction, especially about linguistics and artificial intelligence".
​
![Jacky's photo[80].jpg](https://static.wixstatic.com/media/dd933b_5bc11909925b456ebcee12b66aab27c7~mv2.jpg/v1/fill/w_55,h_82,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/Jacky's%20photo%5B80%5D.jpg)
Jacky Chuen
MSTP PhD Student
"I am a Medical Scientist Training Program (MSTP) student with an interest in cancer immunotherapy. I grew attracted to cancer research because of the unique and novel perspectives it has on targeting cancer. The immune system is powerful and fascinating to me, yet there is still so much to learn about it. My goal is to be able to transform that curiosity into knowledge that will one day help cancer patients in need. During my free time, I like to watch anime, go on walks with my dog, fix things around the house, and eat good food".
​
Harrison Hector
PhD Rotation Student
"I undertook an B.Sc. in Biochemistry and an M.Res. in Musculoskeletal Aging in England before joining the Einstein PhD program. My interests are in cancer and aging research, and I am currently working on deducing the possible mechanisms of cell competition. Outside of science I love football (soccer) and playing music. ".
​
Harrison Hector harrison.hector@einsteinmed.edu
Osayuware Igbinigun
Trainee - MECC High School Summer Research Program
"I am a senior at University Heights High School. I aspire to work in the medical field as a Nurse Practioner. I have worked with Memorial Sloan Kettering Cancer Center and had the opportunity of working at the Montefiore Einstein Cancer Center where I spent 7 weeks of my summer at Dr. Singh’s Lab . I love to support my community in any way that I can whether by supporting children or older people in the world, I am always open to volunteer work, and doing other activities that keep me productive like Track and Field or cycling. Thanks to Dr. Singh's lab, I could give back to the community by investigating and exploring ways to treat Pancreatic Cancer through the art of using scientific instruments and learning what it means to obtain new information by always asking questions. Working with Dr. Singh has not only allowed me to come to self-realization but also have this new pursuit of Genetics and wonder how I can achieve this goal in this vast world of Research".
​